Clinically, the South Asian phenotype is predominantly abdominal obesity resulting in an "apple shaped" body type. Introduction Epidemiological studies have highlighted that the South Asian migrant population in UK have a comparable risk of developing IBD but with a more aggressive phenotype than the white Caucasian population. NW South Asia on the other hand, is by default an East Eurasian admixed region like Central Asia is, where Caucasians are not the norm nor the majority, which is why he passes better there than in Turkey (and as more typical in NW South Asia as well). 1). [12] Asians are prone to visceral adiposity, which is more closely associated with insulin resistance and T2D than overall adiposity. Genetic screening of 2401 US South Asian individuals found an MYBPC3 Δ25bp carrier frequency of 6%. What is my phenotype? - Page 2 - Anthroworld The human gut microbiota is impacted by health status and diet and therefore . Jul 6, 2021 #1 All this took longer than you would expect I legit had to make 3 accounts to do this autistic magnificence. Adult body composition may be predictable in early life. Comparison of Disease Phenotypes and Clinical ... Proctitis was uncommon in South Asian UC patients (9.9 vs. 26.1% in Northern European patients,P<0.0001). South Asian patients that present with NAFLD appear to have lower BMI and obesity rates. We hypothesized that the prevalence of H. pylori infection and diversity of CagA phenotype . Methods We included patients . We have subsequently identified that this unique phenotype accounts for much of the increased heart disease risk in South . This one is mainly in Iran but has some overlap into South Asia mainly into Pakistan. If you're of South Asian origin, you may have heard the term "The Desi Belly" thrown around referring to a stereotypical South Asian person's body with a relatively high amount of belly fat. South Asians, in general, have higher body fat and lower skeletal muscle mass at the same or lower BMIs compared to white people ("high body fat-normal BMI-low muscle mass" phenotype). Studies in the South Asian diaspora residing in the U.K. during the early 1980s suggested the possibility of an Asian Indian or South Asian phenotype (Fig. Mar 7, 2022. full evaluation. The frequency of PON1 QQ, QR and RR phenotype was 56%, 37%, and 7% for Caucasian subjects versus 35%, 44%, and 21% for South Asian subjects (χ (2) = 7.72, P = 0.02). However, the effect of this variant on exercise parameters has not been evaluated.Methods: As a pilot study, 10 asymptomatic SA carriers of the . At similar BMI levels, diabetes prevalence has been identified as higher in Asians compared with caucasians. Abstract. hogrider22. Often shows a variety of ancient features. It has also . The distinct South Asian phenotype, characterized by increased visceral fat, lower muscle mass, and accelerated beta cell decline, plays an important role towards this observation [41, 42]. : comparing cardiometabolic risk factors in the CARRS and NHANES Studies. Background: In the context of rising obesity in South Asia, it is unclear whether the "South Asian phenotype" (described as high glucose, low high-density lipoprotein cholesterol and high triglycerides at normal ranges of body weight) continues to be disproportionately exhibited by contemporary South Asians relative to other race/ethnic groups. 1. I do hear from many others regarding Saudis being racists towards em, even my Syrian and Egyptian friends themselves told me this. of DKA should be described as "atypical diabetes" is being recognized the same regardless of the apparent phenotype of the increasingly worldwide; being originally described in KPD patient, and that all KPD patients should be African population has . The vast majority of the Indians look very similar states like up, bihar, most of south India, central India and up to gujarat in the northwestern part of India all look very similar in phenotype and brahmins in Bihar depsite having such high r1a1 look no different from your average Indian and phenotypically overlap more with a southern brahmin than with a northwestern brahmin. Predictors of the thin-fat phenotype, according to Dr Anand, include South Asian ethnicity. We carried out a study to determine whether paraoxonase 1, a novel biomarker for cardiovascular risk, was decreased in South Asian compared with Caucasian renal transplant recipients. 63.0% of South Asian UC patients had extensive colitis compared with 42.5% of the Northern European cohort (P<0.0001). "Despite having a low [body mass index] BMI, South Asians have increased percent body fat as well as . Comparing Cardiometabolic Risk Factors in the CARRS and NHANES Studies Joined. Is the "South Asian Phenotype" Unique to South Asians? If you have genes of Indian descent you face a unique problem when it comes to your health and fitness. This study describes the phenotype, genotype and clinical outcomes of a South-Asian PRKAG2 cardiomyopathy cohort over a 7-year period. Migrated to Australia via a South Asian route. [13] Most common in Afghanistan and Iran with some overlap into Pakistan and West India. The concept of the "Asian Indian phenotype" was developed as a corollary to these studies. 2. middle-income regions. A . RESULTS In this genotype-phenotype study, individuals of South Asian descent living in the United States from both sexes (36.23%female) with a mean population age of 48.92 years (range, 18-84 years) were recruited. PON1 mass and arylesterase activity . For the second aim, 28 South Asian and 24 European participants were chosen at random (but matched for age) within 4 months of their original main study visit to undergo magnetic resonance spectroscopy for quantification of liver fat. 9,656. The phenotype of IBD differed significantly between the two populations. South Asia also forms one of the epicentres of diabetes. This study describes the phenotype, genotype and clinical outcomes of a South-Asian PRKAG2 cardiomyopathy cohort over a 7-year period. Objective Given the South Asian phenotype of higher body fat at similar body mass index (BMI) relative to Caucasians, we sought to explore the association between prominent adiposity indicators with blood pressure (BP) and hypertension, to compare the accuracy of these indicators in estimating hypertension, and to provide cut-off values associated with adverse hypertension risk in South Asian . Age-and Sex-Adjusted Prevalence of Total Diabetes . South Asian version of flatbush diabetes mellitus- A case report and review article . Because of the presence of multiple risk factors and a body composition conducive to the Thin-fat insulin-resistant phenotype also present in South Asian neonates born in the Netherlands - Volume 6 Issue 1 Genetic screening of 2401 US South Asian individuals found an MYBPC3 Δ25bp carrier frequency of 6%. By Shivani A. Patel, Roopa Shivashankar, Mohammed K. Ali, R. M. Anjana, M. Deepa, Deksha Kapoor, Dimple Kondal, Garima Rautela, V. Mohan, K.M. South Asian renal transplant recipients have a higher incidence of cardiovascular disease compared with Caucasian renal transplant recipients. Full size image. Cardiovascular disease, diabetes mellitus, and chronic kidney disease account for 27%, 4.0%, and 3.0% of deaths, respectively, in South Asia [1•].There is an appreciable increase in obesity in all South Asians countries [].The existing trend indicates that obesity is increasing among both genders (see further discussion below) and in children and adolescents [3, 4]. East Indians falls somewhere between but many can look closer to South Indians. Abstract. New Zealand and Easter Island were reached in the Middle Ages, sometimes replacing older . While genetic factors might contribute a little to the south Asian phenotype, the current diabetes epidemic is fuelled predominantly by lifestyle, which is related to environmental factors. Indo Nordic Votes: 2 7.1% North Indid Votes: 11 39.3% Indo Brachid Votes: 1 3.6% Keralid Votes: 1 3.6% Malabarese Votes: 2 7.1% Indo Melanid Votes: 2 7.1% Gracile Indid Votes: 2 7.1% Mountain Indid Votes: 2 7.1% East Brachid Votes: 4 14.3% Other. 84d 7h 36m. Download Citation | Diabetes in South Asians: Phenotype, Clinical Presentation, and Natural History | Purpose of review: South Asia is one of the epicenters of the global diabetes pandemic . Genetic components play important roles in the pathogenesis of PCOS, and genome-wide association studies of PCOS suggest that similar genetic risk factors . Superciliary arches strong, prognathy, long skulls, receding chin and foreheads. south Asians present with greater metabolic risk at lower levels of BMI compared with other ethnic groups (referred to as the south Asian phenotype), with type 2 diabetes often developing at a younger age, and with rapid progression of diabetic complications. Age-adjusted mortality at 1 year after ACS in South Asian compared with white patients according to demographic, risk factor, disease phenotype and management characteristics (n=203 092) Thus, throughout these stratified analyses, there were no strata in which South Asians had a worse prognosis than white subjects. Probably split off from one of the early Out-of-Africa migrations before the divergence of Europeans and East Asians. In addition, excess abdominal adiposity, typically seen in South Asians, and increased hepatic fat (non-alcoholic fatty liver disease) are associated with an . Demographic data collected included current age, age at diagnosis, age at presentation to our clinic, race (white or South Asian), tobacco use (defined as cigarette smoking or oral tobacco use at the time of most recent office visit), duration of follow-up at our clinic, number of clinic visits, and family history of IBD. Background South Asian children and adults have a more adipose body composition compared with those of European ancestry. Ethnic south Asians present with greater metabolic risk at lower level of BMI compared with other ethnic groups (referred to as the south Asian phenotype), with T2DM often developing at a younger age, and with rapid progression of diabetic complications. However, little is known about how early in life such . Intro. This article will therefore focus primarily on these two factors and examine how . Unlike East Asian patients, South Asian patients showed an increased degree of hirsutism, early onset of symptoms, and severe insulin resistance and metabolic risks compared with Caucasians. Asian Indian Phenotype (Thin-Fat Asian Indian) At any body mass index (BMI) and age, Asian Indians have higher body fat, visceral fat and waist circumference (WC); lower skeletal muscle mass; thinner hips; short legs; profoundly higher rates of insulin resistance, metabolic syndrome, diabetes, dyslipidemia hypoadiponectinemia, and increased cardiovascular risk than Europids. In the context of rising obesity in South Asia, it is unclear whether the "South Asian phenotype"(described as high glucose, low high-density lipoprotein cholesterol, and high triglycerides at normal ranges of body weight) continues to be disproportionately exhibited by contemporary South Asians relative to other race/ethnic groups. It remains unclear if this is due to environmental/lifestyle factors or differences in host genetics. Joined May 19, 2019 Posts 27,289 Reputation 23,348. Background: In the context of rising obesity in South Asia, it is unclear whether the "South Asian phenotype" (described as high glucose, low high-density lipoprotein cholesterol and high triglycerides at normal ranges of body weight) continues to be disproportionately exhibited by contemporary South Asians relative to other race/ethnic groups. Paraoxonase 1 was measured by mass, arylesterase activity, and two-substrate phenotype assay. You might have family members with conditions like Type 2 Diabetes, heart disease, or PCOS, which all have disproportionately high rates in the South Asian community… PHENOTYPE :- world's 20% of the population Is from South Asia. South Asian Americans- A place for members of the South Asian diaspora that includes people who descend from Bangladesh, India, Maldives, Pakistan, Afghanistan, Sri Lanka, Bhutan, and Nepal. Some assume similarities with the first Polynesid variety that migrated from South-East Asia into Oceania. This series from The Lancet Diabetes & Endocrinology examines the growing epidemic of type 2 diabetes in South Asia in recent decades. His 12-lead ECG demonstrated 10 mm of ST-segment elevation in leads V 2 through V 6, and he received fibrinolytic therapy within 90 minutes of symptom onset.His pain resolved, but his ST segments only . Asians, as such, appear to have a distinct "thin outside fat inside (TOFI)" characteristic phenotype of obesity and type 2 diabetes compared to their Western counterparts. Venkat Narayan, Muhammad Masood Kadir, Zafar Fatmi, Dorairaj . 1 ). In the South Asian CD cohort, disease location . The earliest studies on T2D in south Asians focused on the role of insulin resistance as the primary driver for dysglycemia [ 7, 8 ]. Which South Asian Phenotype Do You Identify As? Clinical, electrocardiographic, echocardiographic, and . Background Inflammatory bowel disease (IBD) is increasing in the Asia-Pacific region, with changes in disease phenotype and course. The two most important of these are unhealthy diet and physical inactivity. There are many blurred lines in between, but I noticed some subtle physical difference between the North Indians and South Indians. Clinical, electrocardiographic, echocardiographic, and . We aimed to assess the changing phenotypes of IBD over ten years, describe the early clinical course (ECC) and identify the clinical predictors (CP) of poor outcomes among a large, multi-centre, cohort of Sri Lankan IBD patients. Participants will be followed up over many . South Asians have been characterised by the Asian Indian phenotype. The phenotype depends upon the . Fig. Studies in the South Asian diaspora residing in the U.K. during the early 1980s suggested the possibility of an Asian Indian or South Asian phenotype ( Fig. Abstract. RECENT FINDINGS:South Asia has high incidence and prevalence rates of diabetes. Background. The average phenotype across South Asia. We also welcome Desis who live in Australia, Britain, Canada, and other countries outside of the South Asian subcontinent. This is thought to be related to their increased risk of metabolic disorders. . South Asia Biobank Study is large-scale prospective study which will collect detailed health and life-style information, and biological samples in ~200,000 South Asians aged between 25 and 85 years old living in the UK and South Asia (India, Pakistan, Bangladesh, Sri Lanka). Results In this genotype-phenotype study, individuals of South Asian descent living in the United States from both sexes (36.23% female) with a mean population age of 48.92 years (range, 18-84 years) were recruited. In young South Asians with diabetes diagnosed below 30 years of age, an intriguing Online. The timing of this change now seems much later, however, probably . In addition, the age-standardized incidence rate (ASR) of gastric cancer in Thailand varies with geographical distribution; the ASR in the North region is 3.5 times higher than that in the South region. The three articles review the epidemiology and determinants of the disease and risk factors in the context of economic, nutrition, and physical activity transitions and the South Asian phenotype; describe the clinical management of type 2 diabetes and its . The South Asian phenotype has been invoked to explain, in part, reports of elevated coronary heart disease, events, and cardiovascular mortality among migrant South Asians relative to local populations in diverse settings that date back several decades [4-8]. Farhan Akhtar is half Irani aka Persian, hence the better genetics for lean mass and less fat storage with a carb heavy diet. This term refers to a combination of characteristics that predisposes SA to the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Phenotype group typical for native Australian people. It's called Asian-Indian Phenotype 2: (aka Thin-fat phenotype), and in the modern world, it can be as superficial as looking bad naked or as serious as an early death sentence. Diabetes in south Asians has certain peculiar features with respect to its pathophysiology, clinical presentation, and management. Comparisons were made by using a matched design. This term refers to a combination of characteristics that predisposes SA to the development of insulin resistance, type 2 diabetes, and cardiovascular disease. The Pakhtun region of Afghanistan is certainly South Asian because the Pakhtun communities share 85% of their DNA with Punjabis and nearly 90% with Jats. Is the "South Asian Phenotype" unique to South Asians? Exists mostly in the North of the subcontinent. Every south asian phenotype upscaled OP reptiles; Start date Jul 6, 2021; reptiles I share knowledge freely. BACKGROUND: In the context of rising obesity in South Asia, it is unclear whether the "South Asian phenotype"(described as high glucose, low high-density lipoprotein cholesterol, and high triglycerides at normal ranges of body weight) continues to be disproportionately exhibited by contemporary South Asians relative to other race/ethnic groups. HOMAIR and fasting glucose were 67% (p. 0.001) and 3% (p0 Brief Summary: South Asians have one of the highest rates of heart disease of all populations and a unique and deleterious obesity phenotype of increased body fat and inner-abdominal compared to those of European background. Answer: I am Indian myself who speak fluent Arabic. Which South Asian Phenotype Do You Identify As? The South Asian phenotype of NAFLD appears to differ from that which is presumed in developed nations. This is on top of the absurd phenotype variation you can find within a single family (due to the nature of divergent ancestries in South Asia). Objective: Anthropometric . This "South Asian Phenotype" makes them more prone to develop hyperglycemia and cardiovascular disease at a relatively young age, a feature that has been seen in other ethnic groups as well (eg, Chinese). crusher. My wife is a Yemeni Arab. Notably, South Asian neonates born in the Netherlands revealed a thin-fat insulin resistant phenotype compared to a matched Dutch white controls group . Its anti-human laws deviate the natural rhythm of life and make people crazy. The two most common ways to measure abdominal obesity are waist circumference and waist to hip ratio (WHR). V V This region includes three of the most populous countries of the world. But, in my personal experience, I never encountered one ( not even a single one) being. This review aims to summarize some of the recent evidence pertaining to the distinct diabetes phenotype in south Asians. Southern Polynesid variety. In the next post I will include all the common Southern phenotypes. South Asian/Indian Body Type - Part 1: A Genetic "Curse"? Islam is the direct cause of this. Not to mention a seemingly immovable object in the path to the body and health of your dreams. Background: South Asians have a muscle-thin but adipose body phenotype and high rates of obesity-related disease. There is no discernible SSA admixture in your phenotype. Between 8% and 15% of U.S. men and 1% and 2% of U.S. women of diverse race/ethnic backgrounds exhibited dysglycemia and dyslipidemia at levels of body weight considered "healthy," consistent with the cardiometabolic profile described as the "South Asian Phenotype." Urban South Asians, however, were … Background The risk to develop gastric cancer in Thailand is relatively low among Asian countries. In terms of frequency of phenotype, since he looks Castizo in the latest picture, the Best fit is Latin America, followed by Central Asia/Eastern Russia, West Asian and NW South Asia, in order. Last edited by Sapporo; 06-13-2021 at 01:09 AM . Patient Demographics and Disease Phenotype. This observation has come to be known as the 'Asian Paradox'. Genetic components play important roles in the pathogenesis of PCOS, and genome-wide association studies of PCOS suggest that similar genetic risk factors . × . crusher. South Asia is one of the epicentres of the diabetes epidemic and diabetes rates vary from 3.3% in Nepal to 10% in India.2 The so-called "south Asian" or "Asian-Indian" phenotype makes this ethnic group more susceptible to both type 2 diabetes and premature coronary artery disease, compared Bmi levels, diabetes prevalence has been identified as higher in Asians compared with caucasians, Canada, and <... 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